神经内分泌因素与原发性高血压动态血压曲线的关系

The Relationship of Nerve-Secretion Factors and ABPM in Essential Hypertention

目的 探讨神经内分泌因素与原发性高血压患者 2 4小时血压节律的关系。方法 78例原发性高血压患者均检测血浆去甲肾上腺素 (NE)、肾上腺素 (AD)、血管紧张素Ⅱ (ATⅡ )、内皮素 (ET)、神经肽Y(NPY) ,应用统计学方法对化验结果进行分析 ,观察其与 2 4小时血压节律正常组 (杓型组 )及异常组 (非杓型组 )的关系。结果 原发性高血压非杓型血压特点患者去甲肾上腺素水平明显增高 (P <0 0 1) ,而肾上腺素、血管紧张素Ⅱ、内皮素、神经肽Y无明显变化 (P >0 0 5 )。结论 原发性高血压患者血浆去甲肾上腺素水平对 2 4小时血压节律的改变起着重要的作用 ,而肾上腺素、血管紧张素Ⅱ、内皮素及神经肽Y无明显影响。

Objective investigate the relationship between nerve secretion factors and circadian rhythm of blood pressure in patients with essential hypertension. Methods Nerve secretion factors such as plasma norepinephrine(NE), adrenaline(AD), angiotensin Ⅱ(AT), endothelin(ET) and neuro peptide Y(NPY) were examined in 78 patients with essential hypertension. According to the results of ABPM,the patiens were divided into dipper type and non dipper type groups. \{Results\} Compared with dipper groups, NE was significantly higher in non dipper group. AD, AT Ⅱ, ET and NPY had no difference in two groups. Conclusion\ NE might associated to the circadian rhythm of blood pressure in patients with essential hypertension significantly, but not AD, ATⅡ, ET and NPY .