776例畸形、死胎、习惯性流产患者的染色体分析及临床意义

Chromosome Analysis of 776 Couples with Teratosis or Fetal Death or Habitual Abortion and the Clinical Significance

回顾性总结患者核型资料 ,为产前诊断提供依据。对 776例分娩畸形、死胎、习惯性流产患者进行染色体检查 ,共检出异常核型 2 5例 ,占受检人数的 3 2 % ,其中平衡易位携带者 13例 ,臂间倒位 5例 ,性染色体异常 7例。这表明染色体异常是导致畸形、死胎、习惯性流产的重要原因。在遗传咨询门诊中 ,应对患者进行染色体检查 ,若再次妊娠 。

In order to explore the chromosome abnormality and its clinical significance in antenatal diagnosis for couples with teratosis or fetal death or habitual abortion,cytogenetical examination and retrospective karyotype analysis were performed in 776 patients with teratosis or fetal death or habitual abortion It was found that 25 cases in 776 cases were with chromosome abnormality,accounting for 3.2% (8 males,17 females ).Autosome anomaly were present in 18 cases,including 13 equilibrium translocation,5 pericentric inversion,1 number abnormality Anomaly of sex chromosome were present in 7 cases Therefore,it can be said that chromosome abnormality is one of the main causes of couples with teratosis or fetal death or habitual abortion,and karyotype analysis of chromosome is an absolutely necessary method for the cause seeking and genetic counselling of couples with teratosis or fetal death or habitual abortion The instruction is necessary for the next gestation