吡啶鎓盐系列相转移催化剂的制备及性能

Synthesis and Properties of 4-(N’,N’-Dialkylamino)-N-alkyl pyridinium Salts

合成了一系列对芳香亲核取代反应 (氟代反应 )有良好反应活性的 4-二烷基氨基吡啶盐系列相转移催化剂 ,研究了该系列催化剂的催化活性 ,并筛选出活性最佳的催化剂 .在催化活性最好的 4-(二甲氨基 ) -N-(2 -乙基 )己基吡啶盐 (Cat2 )作用下 ,对氯硝基苯氟化 ,得率 98.6% ,反应时间 1 .5 h.

A series of thermal stable phase transfer catalysts based on alkyl pyridium salt were synthesized , their catalytic activities were evaluated in the typical aromatic nucleophilic substitution reaction(fluorination). Among the catalysts prepared 4 ( N,N dimethylamino) N ethylhexyl pyridinium salt(Cat 2) exhibited the highest catalytic activity. It give p nitrofluorobene in yield up to 98 6% in 1 5 h reaction.