益肾降压方对肾实质性高血压及RAS系统物质的作用研究

Research of Shen-tonifying and Pressure-reducing Recipe to Renal Hypertension and RAS System Matter Action

目的:研究益肾降压方降低肾实质性高血压(RPH)大鼠血压、改善肾功能的作用及机制。方法:采用大鼠5/6肾切除术法建立RPH模型。动态测定血压、肌酐、尿素氮,以及在给药8周后测定血浆肾素活性(PAR)、血管紧张素(AⅡ)、血栓素(TXB_2)、6-酮-前列环素(6-keto-PGF_(1α))的含量。结果:各剂量益肾降压方均可降低RPH大鼠的血压(BP)、肌酐(Cr)。但对RPH大鼠尿素氮(BUN)未见影响;各剂量益肾降压方可显著降低血浆PAR、AⅡ,同时还可显著降低TXB_2含量,升高血浆6-keto-PGF_(1α)含量。结论:益肾降压方可降低RPH大鼠的血压,并对肾脏具有保护功能;益肾降压方的降压作用和对肾脏的保护功能是通过影响RPH大鼠肾素-血管紧张素-醛固酮系统而完成。

To study the effect and mechanism of Shen-tonifying and pressure) reducing recipe, a prescription of Chinese traditional herbs used for renal hypertension, on reducing blood pressure and protecting renal function of RPH rats. The 5/6 kidney of rats was resected to set up the RPH rat model. Blood pressure, creati-nine (Cr) and blood urea nitrogen (BUN) were determined dynamically. At the end of the eighth week, plasma content of PAR AⅡ TXB2, 6-keto-PGF1α were determined. The result shows that Shen-tonifying and pressure-reducing recipe could reduce blood pressure and Cr; but had no effect on BUN of rats; the index of PAR AⅡ of each group of Shen-tonifying and pressure-reducing recipe was decreased; at the same time, it reduced plasma content of TXB2, increased 6-keto-PGF1α. So Shen-tonifying and pressure-reducing recipe can reduce blood pressure of RPH rats and have protective function to their kidneys and perform its effect of reducing blood pressure and protecting kidney by influencing the RAS of RPH rats.