纳曲酮两种给药方法依从性的比较

COMPARISON OF TWO DIFFERENT ADMINISTRATIONS OF NALTREXONE

目的·· :比较脱毒后立即足量服用和常规逐渐递增至足量服用纳曲酮的服药依从性。方法·· :从1999年5月至2000年9月间来我院自愿戒毒的患者中筛选68例脱毒者 ,随机分为A、B两组 ,每组34例 ,分别对立即足量服用(A组)与常规逐渐增至足量服用(B组)两种给药方法的依从性进行比较。结果··:A组1周内服药依从率为88.2% ,B组为47.1 %,两组有显著性差异 (P<0.01) ;6个月时A(36.7 %)、B(37.5 % )两组的依从率无显著性差异,但A组 (11例 )保持操守人数多于B组 (6例 )。结论·· :临床脱毒后立即进入足量纳曲酮维持治疗 ,可缩短诱导期 ,降低脱失率 。

Objective: To compare the effects of two methods of naltrexone administration. Methods: 68 heroin addicts selected from the patients who undertook voluntary detoxification during May 1999 to September , 2000 were divided randomly into A and B groups(34 cases/per group). Patients in Group A took full dose (50 mg·d-1) of domestic naltrexone immediately after acute detoxification for one week; patients in Group B took naltrexone by progressive dose from 5 mg·d-1 to 50 mg·d-1 within the first seven days. Then a six-month follow-up was conducted. The anti-relapse effectiveness was compared. Results: There were 30 patients (88.2%) continuing naltrexonetreatment in Group A, while 16 patients (47.1%) left in Group B after the first week. By the end of the sixth month, 11 cases(32.3%) consisted in naltrexone treatment in Group A, 6(17.6%) left in Group B. Conclusion: The anti-relapse effectiveness of immediate full dose naltrexone administration is significantly better than progressive dose of administration.