家族遗传性结肠息肉病恶变过程中PCNA变化

Changes of proliferation cell nuclear antigen in the carcinogenesis of FPC

目的 为研究家族遗传性大肠息肉病 (FPC)恶变演变过程。方法 采用LAB免疫组化染色对 2 9例家族遗传息肉病 ,2 4例大肠癌和 2 8例腺瘤性息肉增殖细胞核抗原 (PCNA)进行对比研究。结果 在恶变FPC和大肠癌组织中PCNA表达较高 ,明显高于恶变FPC组未恶变息肉 ,未恶变FPC组息肉和腺瘤性息肉 (P <0 .0 1) ;恶变FPC组织PC NA表达明显高于大肠癌组织 ,有显著差异 (P <0 .0 5 ) ;恶变FPC组中未恶变的息肉明显高于未恶变FPC组息肉和腺瘤性息肉 ,有显著差异 (P <0 .0 5 ) ;未恶变FPC组息肉PCNA表达与腺瘤性息肉比较无显著差异 (P <0 .0 5 )。结论 FPC恶变演变过程是逐渐发生的 ,应进行连续监测 ;FPC一但恶变 ,恶性程度较高 ,易发生转移 ,预后较差 ;FPC恶变后另一些未癌变息肉尽管没有癌变但已属于高危癌前病变 ,手术中应将所有息肉一并切除。

Objective To study the carcinogenesis of familial polyposis of the colon(FPC).Methods Proliferation cell nuclear antigen (PCNA)was determined and studied in 29 samples of FPC,24 carcinoma of large intestine and 28 samples of polyposis by LAB method.Results The expression of PCNA in cancer tissues was significantly higher than that in polyposis of both cancerous and non cancerous FPC group. (P<0.01);PCNA in cancerous tissues of FPC group was higher than that in dispersed carcinoma of large intestine (P<0.05).Conclusion The carcinogenesis of FPC is gradual,and in the early period of carcinogenesis,obvious changes exist in PCNA.Thus continous watch on FPC is necessary.Once it happens,the malignancy of FPC is severe and has poor prognosis, and early radical resection should be taken as soon as possible.