P_(53)和bcl-2在宫颈上皮内瘤样变及宫颈癌中的表达

The overexpression of P_(53) and bcl-2 in CIN and cervical carcinomas

目的 探讨P53 和bcl 2表达产物在宫颈癌中过度表达的意义及二者间的相互关系。方法 采用免疫组化SP法分别对 10例宫颈上皮内瘤样变和 5 7例宫颈癌中P53 蛋白和bcl 2蛋白进行了检测 ,并以 11例正常宫颈鳞状上皮作对照。结果 P53 蛋白在CIN中的表达与对照组间差异显著 (P <0 .0 1) ;P53 蛋白在宫颈浸润癌中的表达与对照组间有显著性差异 (P <0 .0 1) ;P53 蛋白在CIN与宫颈浸润癌中的表达差别无显著性 (P >0 .0 5 ) ;P53 蛋白在宫颈浸润癌病理Ⅱ级和Ⅲ级中的表达明显高于病理I级 (P <0 .0 5 ) ;P53 蛋白在宫颈癌结节型中的表达明显高于溃疡型 (P <0 .0 5 ) ;bcl 2蛋白在CIN中的表达强度明显高于对照组 (P <0 .0 5 ) ;bcl 2蛋白在宫颈浸润癌中的表达不仅表达率而且表达强度均明显高于正常对照 (P <0 .0 1) ;bcl 2蛋白在宫颈癌中的表达与在CIN中的表达差别无显著性 (P >0 .0 5 ) ;在宫颈癌中P5 3蛋白表达和bcl 2蛋白的过表达间有明显正相关 (P <0 .0 5 )。结论 P53 和bcl

Objective To probe the significance of overexpression of P 53 and bcl 2 protein in CIN and in carcinogenesis of cervix.Methods 10 cases of CIN and 57 cases of invasive cancer were investigated with immunohistochemistry technique.Results The overexpression of P 53 protein in CIN and in cervical cancer was remarkably higher than that in the control (P<0.01),and the difference between CIN and cervical cancer was not significant (P>0.05).The immunoreactivity of bcl 2 in CIN was higher than that of control (P<0.05).Both of the positive rate and immunoreactivity of bcl 2 in cervical carcinoma were remarkably higher than those in the control(P<0.01),but there was no significant difference between CIN and cervical carcinoma (P>0.05).There was a remarkably positive correlation between the overexpression of bcl 2 and P 53 (P<0.05).Conclusion The overexpressions of P 53 and bcl 2 are associated with the pathogenesis and development of cervical carcinoma.