老年性抑郁症患者的伴随负电位变异研究

Study of contingent negative variation in patients with aged depression

目的 :探讨老年性抑郁症患者的伴随负电位 (CNV)变异。方法 :记录 2 1例老年性抑郁症患者的事件相关电位CNV ,并与 33例正常对照者和 39例非老年期的抑郁症患者的CNV进行比较。结果 :老年性抑郁症患者的CNV变化与非老年期的抑郁症患者的CNV变异基本类似 ,但CNV波幅降低更明显、命令后伴随负电位 (PINV)出现率更高 ,反应时间进一步延长。结论 :CNV可以作为评定老年性抑郁症患者大脑综合功能的辅助方法之一。

Objective:To investigate the contingent negative variations (CNV) in patients with aged depression.Methods:An event-related potential CNV was recorded in 21 patients with aged depression and was compared with that of 33 normal controls and 39 patients with non-aged depression.Results:The CNV presentation of patients with aged depression was similar to that of non-aged depression,but with a lower amplitude,a higher incidence of postimperative negative variation (PINV) and further prolonged reaction time.Conclusions:CNV might be one of methods for assessing the synthesizing function of the brain in patients with aged depression.