速可眠、三唑仑、唑吡坦、佐匹克隆催眠效果的神经电生理特征

Neurophysiological features of hypnosis efficiency of secobarbital,trazolam,zolpidem and zopiclong

目的 :比较速可眠 (SEC)、三唑仑 (TZL)、唑吡坦 (ZP)、佐匹克隆 (ZPL)催眠效果的多道睡眠图 (PSG)特征。方法 :对 8名 (18～ 2 0岁 )健康男性青年志愿者进行PSG描记 ,观察口服SEC、TZL、ZP、ZPL后觉醒时间 (AT)、睡眠潜时 (SL)、实际睡眠时间 (AST) ,睡眠效率 (SE) ,睡眠分期 (S1、S2 、S3 + 4 、REMS)的变化。结果 :4种催眠药的AT未见明显增加 ,AST未见明显减少 ,催眠效率均大于 85 %。SEC组SL短于其它 3组 ,SEC对增强S3 + 4 、REM睡眠期的作用显著。结论 :4种催眠药均通过缩短SL ,减少AT ,相对增加AST而提高催眠效率 ,差异不显著 ,但SEC对睡眠结构的影响较TZL、ZP、ZPL明显。

Objective:To compare the polysomnographic features of hypnosis efficiency of secobarbital (SEC),triazolam(TZL),zolpidem (ZP) and zopiclong (ZPL) during sleep.Methods:Polysomnography was recorded in 8 healthy male youth voluntcersso as to observe the changes of awake time (AT),sleep latentcy (SL),actual sleep time (AST),sleep efficiency (SE) and sleep stages (S 1 ?S 2 ?S 3+4 ?REMS),after taking in SEC,TZL,ZP and ZPL.Results:The AT of the above four hypnotics was not in creased,and the AST was not decreased.The hypnosis efficiency was more than 85%.The SL of SEC group was shorter than the other three group.SEC had significant influence on the stage of S 3+4 and REMS.Conclusions:The four hypnotics might increase the hypnosis efficiency by decrease of SL and AT,and increase of AST.SEC might have significant influence on the sleep structure than TZL,ZP and ZPL.