益心颗粒治疗冠心病心绞痛机制研究

Clinical observation of the effect of Yixin granule(益心颗粒) in treating angina pectoris patients

目的 :观察益心颗粒治疗冠心病心绞痛的临床疗效及对内皮功能的影响。方法 :选取冠心病心绞痛患者 5 5例 ,随机分为 2组 ,分别给予益心颗粒和消心痛治疗 2周。结果 :益心颗粒组和消心痛组均可明显改善冠心病心绞痛患者的临床症状 ,益心颗粒组总有效率为 85 .71% ,消心痛组总有效率为 88.89% ,2组间无显著性差异 (P>0 .0 5 )。血清一氧化氮 (NO)含量均明显增加 ,益心颗粒组治疗前 (2 1.76± 2 .6 4 )μmol/ L ,治疗后(31.2 3± 3.76 )μmol/ L ,P<0 .0 5 ;消心痛组治疗前 (2 2 .87± 2 .79)μmol/ L ,治疗后 (32 .96± 3.5 6 )μmol/ L ,P<0 .0 5。内皮素 (ET)水平均降低 ,益心颗粒组治疗前 (6 5 .87± 10 .32 ) ng/ L,治疗后 (49.98± 7.73) ng/ L,P<0 .0 5 ;消心痛组治疗前 (6 3.73± 9.34) ng/ L,治疗后 (46 .2 3± 7.93) ng/ L,P<0 .0 5。治疗后 2组 NO和 ET间比较均无显著性差异 (P均 >0 .0 5 )。结论 :益心颗粒能缓解冠心病心绞痛的临床症状 ,改善其内皮功能 ,其作用机制之一是通过增加 NO、抑制 ET而介导的。

Objective:To assess the efficacy of Yixin granule(益心颗粒) in treating angina pectoris and its effect on endothelial function.Methods:Fiftyfive patients with angina pectoris were enrolled in the study by a randomized clinical trial treated with Yixin granule or isosorbide mononitrate(IM).Results:The symptoms of both groups were significantly improved,the total effective rate of Yixin granule and IM were 85 71% and 88 89% respectively( P >0 05).The level of serum nitric oxide(NO) was increased from(21 76± 2 64) μmol/L before therapy to (31 23±3 76) μmol/L after therapy in Yixin granule group ( P <0 05) and from (22 87±2 79) μmol/L to(32 96±3 56) μmol/L in IM group ( P <0 05),the serum endothelin(ET) was decreased from(65 87±10 32) ng/L to (49 98±7 73) ng/L in Yixin granule group ( P <0 05) and from(63 73±9 34) ng/L to (46 23±7 93) ng/L in IM group( P <0 05).There was no significant difference between these two groups (all P >0 05).Conclusions:Yixin granule can effectively improve the symptoms of angina pectoris,the mechanism of which may likely be mediated by NO and ET.