葛根素注射液与临床常用的10种药物配伍稳定性考察

Investigation on Compatible Stability of Puerarin Injection With 10 Commonly-used Drugs

目的 :研究葛根素注射液与临床常用的10种药物配伍的稳定性。方法 :观察配伍液的外观 ,测定配伍液的pH值、微粒和葛根素的含量变化。结果与结论 :葛根素注射液与三磷酸腺苷、辅酶A、三氮唑核苷配伍后 pH有显著改变 ,不宜配伍应用 ;与维生素B6、氯化钾、酚磺乙胺、西米替丁、庆大霉素、丁胺卡那霉素、红霉素配伍后 ,外观、pH、微粒及葛根素相对含量无显著性改变 。

OBJECTIVE:To study the compatible stability of puerarin injection with 10 commonly-used drugs.METHODS:The changes in appearance,pH,particulate and puerarin content after mixing with 10 drugs were observed and assayed.RESU_LTS & CONCLUSION:Puerarin injection mixing with adenosine triphosphate,coenzyme A and ribavirin showed significant change in pH,which indicats that they are incompatable each other,however,when puerarin injection was mixed with vitamin B6,potassium chloride,etamsylate,cimetidine,gentamycin,amikacin and erythromycin,no significant changes in pH,particulate and puerarin content were found,which indicates their compatibility.