间变型星形细胞肿瘤Ki-67抗原表达及其对预后作用

Expression and significance of Ki-67 in anaplastic astrocytomas

目的 探讨Ki- 6 7抗原在间变型星形细胞肿瘤中的表达及其预后作用。方法 采用S -P免疫组化方法检测 32例原发性间变型星形细胞肿瘤标本中Ki- 6 7抗原的表达。单因素使用Kaplan -Meier法 ,多因素分析使用COX比例风险模型进行预后分析。结果 Ki- 6 7LI为 6 .74%± 3.89%。单因素及多因素分析均显示Ki- 6 7指数是独立的预后因素。Ki- 6 7指数≤ 2 .5 %与 >2 .5 %的患者生存期分别为 (4 1.30± 13.0 3)月、(2 9.5 3± 9.0 6 )月。结论 在间变型星形细胞肿瘤中 ,Ki- 6 7指数不同 ,其预后有显著性差异。Ki- 6 7指数 >2 .5 %提示预后较差。

Objectives To determine the value of Ki-67 labeling index obtained using MIB-1 monoclonal antibody in predicting survival of patients with anaplastic astrocytomas.Methods Ki-67 was determined with immunohistochemistry using monoclonal antibody MIB-1 in 32 patients with anaplastic astrocytomas.For the univariate analysis,survival probabilities were estimated based on Kaplan-Meier's product limit survival estimates method and logrank test was used to assess the association between patient survival and each variable.Multivariate regression analysis using Cox's proportionalhazards model was used to ascertain a simultaneous effect of outcome-related variables on survival.Results The Ki-67 LI was 6.74%±3.89% The mean survival periods of patients with Ki-67 LI≤2.5% and those with Ki-67 LI>2.5% were (41.30±13.03)months,(29.53±9.06)months,respectively(P<0.01).Conclusions In the same histologic grade(anaplastic astrocytomas,Grade Ⅲ),there is a significant difference in paient's prognosis due to the different Ki-67 LI.And Ki-67 LI>2.5% is a significant factor for shorter survival.