环丙沙星结晶热力学研究

Study on the Thermodynamics of Crystallization of Ciprofloxacin Hydrochloride Mononydrate

测定了环丙沙星的熔化温度和熔化热 ,收集了不同配比的水 /乙醇溶液中环丙沙星的溶解度数据 ,建立了环丙沙星在水 /乙醇溶液中的溶解度模型 ,导出了环丙沙星活度系数与溶剂化常数的关系式 ,估算了环丙沙星的溶解热和溶剂化焓变 。

The melting temperature,the melting heat and the solubility of ciprofloxacin hydrochloride monohydrate in water/ethanol solution are measured in this paper.The solubility model and the expression of the relationship between the activity coefficient and the solvation constant K of ciprofloxacin hydrochloride monohydrate have been established.The dissolution heat and the solvation energy of ciprofloxacin hydrochloride monohydrate in water/ethanol solution have been estimated using the experimental solubility data.This study aims at supplying valuable thermodynamics data for the industrial manufacture of ciprofloxacin hydrochloride monohydrate.