抗寄生虫治疗对脑囊虫病患者T淋巴细胞影响的观察

The Effect of Etiological Therapy on T Lymphocyte of Patients with Neurocysticercosis

为研究抗寄生虫治疗对囊尾蚴感染者 T淋巴细胞亚群的影响 ,采用吡喹酮、阿苯达唑、干芜散三种药物治疗脑囊尾蚴感染患者 30例 ,同时用碱性磷酸酶桥联酶标法 (APAAP)检测治疗前后该病患者 T淋巴细胞亚群的变化 ,结果发现治疗前囊尾蚴感染病人 CD3+ ,CD4 + ,CD8+淋巴细胞百分比及 CD4 / CD8比值分别为 5 8.12± 6 .0 3,33.2 3± 4 .0 9,2 8.0 1± 2 .32和 1.31± 0 .19;治疗后分别为 6 8.32± 6 .0 3,38.0 7± 5 .89,2 7.91± 3.0 2和 1.4 2± 0 .2 8,已趋于正常 ,表明囊尾蚴感染患者 CD3+ ,CD4 +淋巴细胞百分比明显降低 ,CD4 / CD8比值亦降低 ,说明囊尾蚴感染可导致患者免疫功能低下 ,免疫调节机能紊乱 ,呈免疫抑制状态 ,当脑囊尾蚴感染患者接受合理有效的抗囊虫治疗后 ,随着体内囊尾蚴的逐渐死亡 ,CD3+ ,CD4

In order to study the effects of anti parasite therapy on T lymphocyte after cysticercus infection, thirty patients with neurocysticercosis were treated with praziquantel, albendazole and Gan Wu pulvis, meantime, the fluctuation of T cell subgroup was assayed with Alkaline phosphatase anti Alkaline phosphatase. Before treatment, the percentages of CD 3 +,CD 4 +,CD 8 + lymphocytes and the CD 4/CD 8 ratio of patients were 58.12±6.03,33.23±4.09,28.01±2.32,1.31±0.19, respectively.After treatment, they were 68.32±6.03,38.07±5.89,27.91±3.02, 1.42±0.28. The percentages of CD 3 +,CD 4 + lymphocytes in peripharal blood of the patients with neurocysticercosis were obviously lower and the CD 4/CD 8 ratio was also low. These indicated that before treatment,the immunoregulation function and immunocompetence of the patients were very poor. After effective anti cysticercus treatment, along with the dying of cysticercus, the immunoregulation function and immunocompetence of the patients returned to normal.