不同药物治疗小儿咳嗽变异性哮喘44例疗效观察

Curative Effect Observation of Different drugs treatingChildren Cough Variablity Asthma in 44 Cases

目的 观察不同药物组合对小儿咳嗽变异性哮喘的疗效。方法 将44例咳嗽变异性哮喘患儿随机分为三组:舒喘灵＋酮替芬组18例(S-K组);氨茶碱＋赛庚啶组13例(A-S组);抗感染＋祛痰、止咳组13例(对照组)。结果15天止咳总有效率 S-K组为 100%、A-S组为 92．0%,两组比较P＞0．05,但是均明显优于对照组(38．4%),P＜0．01、0．05;S-K组复发率(11．1%),A-S组复发率(30．8%),两组比较,P＞0．05;转化为典型支气管哮喘 S-K组(33． 3%),与对照组(69．2%)有显著性差异,P＜0．05,A-S组(53．8%)与对照组无差异,P＞0．05。结论舒喘灵＋酮替芬和氨茶碱＋赛庚啶两种疗法对咳嗽变异性哮喘均有良好的治疗作用且适用于对吸入疗法不合作的婴幼儿患者;舒喘灵＋酮替芬可有效地防止其转化为典型支气管哮喘,应是基层医院优先选用的药物组合。

ve To investigate the curative effect of different drugs treating children cough variablity asthma. Methods 44 cases of patients were randomly divided into 3 groups treated with Ventolin and Ketotifen(S-K group, 18 patients); Aminophyllini and aperiactin (A-S group, 13 cases); anti -infection expectorant and antitussive (contrast group, 13 cases) Results S-K group(100% ) and A-S group(92. 2%) had antitussive effect, both were much better than contrast group(38. 4% ), P<0.01, 0.05 in 15 days. S-K group (11.1%), A -S group (30. 8%) had no difference in recourrence rate, P>0. 05. Obvious difference existed in conversion to typical bronchial asthma between S -K group(33.3%) and contrast group (69. 2% ), but no difference between A-S group (53. 8% ) and contrst group. Conclusion 1 Ventolin plus Ketotifen and Aminophyllini plus Periactin have better treatment effect to cough variablity asthma, and suit incooperative infants to inhalation therapy. 2 Ventolin plus Ketotifen should be first chosen drug in treatment of bronchial asthma in clinic.