阿霉素介入性化疗与热化疗对兔肝VX-2移植癌改良模型作用的比较研究

Comparative study of the effect of thermochemotherapy of ADM on the retrofit model of VX-2 carcinoma in rabbit liver curative effect of heated chemotherapy via hepatic artery in VX-2 rabbit model

目的 评价介入性热化疗对兔肝癌的抑瘤效果。方法 将VX 2瘤细胞接种于 6 0只新西兰白兔肝右叶 ,建立兔肝癌模型 ,随机分 4组 ,每组 15只。利用导管经肝动脉分别给生理盐水、37℃盐水 +阿霉素、6 0℃热生理盐水及ADM溶液 (6 0℃ )于不同组 ,1周后后观察各组肿瘤体积及血清AST水平 ,观察荷瘤兔的存活期。结果 ADM溶液 (6 0℃ )热灌注组生长率 (0 .5 3± 0 .2 1)与对照组 (3.4 8± 1.17)相比有显著性差异 (P <0 .0 1) ,与栓塞组 (1.13± 0 .2 3)、ADM溶液 (37℃ )灌注组 (1.0 9± 0 .2 6 ) )相比亦有显著性差异 (P<0 .0 5 )。ADM溶液 (6 0℃ )热灌注组存活期 (5 0 .0± 2 .0d)与对照组 (40 .5± 3.0d)相比差异有显著性 (P <0 .0 5 )。ADM溶液 (6 0℃ )热灌注组血清AST水平治疗前后变化与其它各组相比无显著性差异 (P >0 .0 5 ) ,与对照组相比有显著性差异 (P <0 .0 5 )。结论 ADM溶液 (6 0℃ )热灌注组可大大降低肿瘤生长率 ,延长存活期 ,对肝功的损害是可逆的 。

Objective To evaluate the anti\|tumour effects of ADM(Adriamycin) in different temperature which was injected via hepatic artery of VX\|2 rabbits.Methods VX\|2 carcinoma cells were surgically implanted into the right liver lobe of 60 male New Zealand white rabbits,which were divided into 4 groups at random,with 15 rabbits for each group.To inject ADM(37℃),ADM(60℃), 37℃ saline and 60℃ saline in different groups via hepatic artery and embolize liver cancer of rabbits.1 week later,to observe the volume of tumour,the serum level of AST,and observe the survival period of VX\|2 rabbits.Results In group of ADM(60℃), the tumour's growth rate (0.53±0.21)was significantly lower than the other treated groups(1.13±0.23,1.09±0.26)( P <0.05),being significantly lower than the untreated control group (3.48±1.17) ( P <0.01). The survival period of ADM(60℃) group (50.0 ±2.0) was significantly higher than the untreated control group (40.5 ±3.0, P <0.05).The serum level of AST of TNP\|470 with lipiodol group was not higher than the other treated groups( P >0.05),but being significantly higher than the untreated control group after treated( P <0.05).Conclusion ADM(60℃) greatly decreases the tumour's growth rate , and prolongs the survival period .In brief,it has a stronger inhibitory effect than other groups.