放射和高聚生对小鼠膀胱癌生长的抑制作用

The lnhibitory effect of radiation and HASL on the grouth of BTT_(739) mouse bladder carcinoma

目的 研究放射和高聚生 (HASL)对小鼠膀胱癌生长的抑制作用。方法 将BTT739肿瘤细胞接种于T739小鼠皮下制成模型 ,观察不同放射剂量及高聚生对局部肿瘤的抑制作用。结果 接种后即给予HASL治疗 ,第 16dHASL组、放射 5Gy组、放射 5Gy加HASL组的抑瘤率依次为 34%、5 3.2 %、5 2 .9%。接种后 7d给予HASL治疗 ,抑瘤率依次为 2 7.0 %、5 4.9%、6 4.6 % ,放射 8Gy组、放射 8Gy加HASL组依次为 80 .7%、84 .1%。结论 HASL对局部肿瘤生长有抑制作用 ,但与放射联合时不增加放射对肿瘤的抑制作用。

Objective To study the inhibitory effect of radiation and HASL on the grouth of BTT 739 mouse bladder carcinoma.Methods Using the animal model of T 739 mice that be inoculated subcutaneously with BTT 739 mouse bladder carcinoma,We observed the effect of different radiation dose and HASL on the grouth of carcinoma.Results If the HASL was given from the first day after tumour inoculating,the tumour grouth was inhibited by 34%( P <0.05) in the sixteenth day .The tumour inhibition rate were 53.2% in radiation 5 Gy group and 52.9% in radiation 5 Gy in combination with HASL group. If the HASL was given from the seventh day after tumour inoculating, The tumour inhibition rate were 27% ?54.9% and 64.6% respectively. The tumour inhibitionrate were 80.7% in radiation 8 Gy group and 84.1% in radiation 5 Gy in combination with HASL group.Conclusion The HASL alone can inhibit the grouth of BTT 739 Mouse Bladder Carcinoma ,but showed little or no effect when using in combination with radiation.