pS2蛋白在乳腺癌中的表达及意义

Expression and significance of pS2 protein in breast cancer

目的 研究 pS2蛋白在乳腺癌中的表达及其临床意义。 方法 应用免疫组化S P法检测 10 0例原发性乳腺癌患者雌激素调节蛋白 pS2的表达。 结果 10 0例乳腺癌患者中 ,pS2阳性表达 5 7例 ,占5 7% ,阴性表达 4 3例 ,占 4 3% ;pS2阳性表达与月经状况、ER、PR相关 ,与肿瘤大小、临床分期、淋巴结状况无关 ;pS2阳性表达者较阴性表达者五年生存率高 ,复发率低。单因素分析显示 ,pS2蛋白与乳腺癌患者的预后相关 ,pS2阳性表达者的预后优于 pS2阴性表达者 (P =0 .0 0 0 8,风险比 0 .370 )。多因素分析显示 ,pS2是影响患者术后生存的重要生物学指标。结论 pS2蛋白可能是预测乳腺癌患者预后的一个独立的预后因子。

Objective To study the expression and significance of pS2 protein in breast cancer . Methods Applying immunohistochemical technique(S\|P) , pS2 protein in 100cases of breast cancer was detected . Results There were 57 patients with pS2 protein positive expression ,and 43 with negative expression . There was significant correlation between pS2 protein and menopausal status ,ER status , PR status respectively . Neither tumor size , clinical stage ,nor lymph node status was significantly related with the expression of pS2 protein . Patients with pS2 protein positive expression had higher 5\|year\|survival rate than those with pS2 protein negative expression . Univariate analysis showed that pS2 protein was correlated with the prognosis of breast cancer , prognosis of patients with pS2 positive expression was better than that with negative expression ( P =0.0008 , hazards ratio 0.370) . Multivariate regression analysis indicated that pS2 protein was an important biologic marker affecting relapse and survival after radical\|operation of breast cancer . Conclusion pS2 protein appears to be an independent and valid prognostic factor of breast cancer.