麻黄碱对浅全麻患者中潜伏期听觉诱发电位的影响

Effect of Ephedrine on Middle Latency Auditory-Evoked Potentials During Light General Anesthesia

目的 研究麻黄碱对浅全麻患者中潜伏期听觉诱发电位 (middlelatencyauditoryevokedpotential,MLAEP)的影响 ,以评价麻黄碱对麻醉深度的作用。方法 选择 10例ASA分级Ⅰ -Ⅱ级择期行胃、胆囊手术的患者 ,连续硬膜外阻滞复合N2 O -O2 浅全麻。在硬膜外阻滞成功 ,气管插管、麻醉维持平稳后、手术开始前 ,静脉注射0 .1%麻黄碱 0 .15mg/kg。在注射前、注射后 3min、10min三个时相观察患者心率 (HR)、收缩压 (SBP)、舒张压 (DBP)及平均动脉压 (MBP)的变化 ;监测MLAEP ,测量并记录Nb和P1潜伏期的数值。结果 静脉注射麻黄碱后 3min和10min ,患者HR、SBP、DBP、MBP均升高 ,与注射前相比差异有高度显著性意义 (P <0 .0 1) ;而Nb和P1潜伏期均缩短 ,与注射前相比差异也有高度显著性意义 (P <0 .0 1)。结论 静脉注射麻黄碱可减浅麻醉深度。

Objective To study the effect of ephedrine on middle latency auditory-evoked potentials (MLAEP) during light general anesthesia , and evaluate the influence of ephedrine on anesthesia level. Methods 10 patients (ASAⅠ-Ⅱ) undergoing elective upper abdominal operations were concerned. Anesthesia: epidural anesthesia in combination with light general anesthesia with N 2O-O 2 . After success of epidural anesthesia and tracheal intubation , when anesthesia was smooth , before operation 0.1% ephedrine(0.15 mg/kg) was injected intravenously. These data HR, SBP, DBP, MBP were measured continuously before injection, 3 min after injection, 10 min after injection; the latentcies Nb and P1 of MLAEP were measured and rescorded. Results HR?SBP?DBP?MBP increased significantly 3 min after injection, 10 min after injection compared with these data before injection (P< 0.01); the latencies Nb and P1 decreased significantly compared with these data before injection ( P< 0.01 ).Conclusion Ephedrine injected intravenously can decrease the level of anesthesia .