突发性聋患者血浆一氧化氮、脂质过氧化酶、丙二醛水平的测定

Levels of NO、SOD、GSH-Px and MDA in Patients with Sudden Deafness

目的 探讨突发性聋患者体内一氧化氮 (NO)、超氧化物歧化酶 (SOD)、谷胱甘肽过氧化物酶 (GSH -Px)、丙二醛 (MDA)水平的变化及其临床意义。方法 测定 30例突发性聋患者和 2 0例正常健康人血浆NO、SOD、GSH -Px、MDA的浓度。结果 与正常对照组相比 ,突发性聋患者血浆NO、SOD、GSH -Px浓度显著低于正常对照组 ,而MDA水平显著高于正常对照组 (P <0 .0 1) ;不同程度耳聋组之间NO、GHS -Px无显著性差异 ,而在SOD、MDA之间的差异有显著性。治疗后血浆NO、SOD、GSH -Px的活性明显升高。MDA水平明显降低 ,与治疗前相比有显著性差异。结论 突发性聋患者体内NO、SOD、GSH -Px含量下降 ,而MDA水平增高 ,建议治疗该病可应用NO合成诱导剂和外源性SOD或其他抗氧化剂 ,以提高突发性聋的治疗效果。

Objective To explore the clinic significance of the change in the levels of nitric oxide(NO), superoxide dismutase(SOD), glutathione peroxidase(GSH-Px) and malondialdehyde(MDA) in patients with sudden deafness. Methods The levels of the blood plasma NO, SOD, GSH/Px and MDA in 30 patients with sudden deafness and in 20 healthy people were measured. Results The activities of NO, SOD and GSH-Px in plasma of the patients with sudden deafness were significantly decreased than those in normal people, while the concentration of MDA was significantly increased( P <0.01). In the different groups of hearing loss, there was no difference in the levels of NO and GSH-Px, but there was significant difference in the levels of SOD and MDA( P <0.01). Compared with the patients before treatment, the activities of NO, SOD and GHS-Px were significantly increased in patients after treatment. Conclusion The use of NO inducer and foreign SOD might be advantageous for the treatment of sudden deafness.