摘要
目的 :探讨南沙参多糖 (RAPS)对东莨菪碱所致大鼠学习记忆障碍的影响。方法 :igRAPS 5 0 0～ 2 0 0 0mg/kg每天一次共 15天 ,大鼠穿梭箱法测定学习记忆能力 ,化学荧光法测定单胺类递质的含量。结果 :大鼠主动回避反应率显著增加 ;大鼠脑中NE、DA、5 HT含量增加 ,AchE活性降低 ;血糖含量增加。结论 :RAPS具有改善大鼠学习记忆的功能 ,其作用与影响鼠脑中神经递质及血糖有关。
RAPS potently improves the impairment of learning and memory in rats induced by scopolamine, the rate of active avoidance response was raised significantly. RAPS attenuated reductions of content of NE, DA and 5 HT in rats' brains and g lucose in rats' blood produced by scopolamine. RAPS inhibited AchE activity in r ats' brains.
出处
《中药药理与临床》
CAS
CSCD
2001年第6期19-21,共3页
Pharmacology and Clinics of Chinese Materia Medica
关键词
南沙参多糖
东莨菪碱
学习记忆障碍
Radix Adenophorae
learning and memo ry
scopolamine
active avoidance response
