草血竭抗肿瘤作用的实验研究

Experament study on antitumor effects of Polygonum paleaceum

目的 :研究草血竭提取物的抗肿瘤作用。方法 :体外实验采用台盼蓝拒染法和MTT法 ,体内实验采用小鼠移植性肿瘤S180 和HepA模型。 结果 :草血竭体外抑制K562 和HL60的IC50 为 2 6 2～ 3 6 7mg/L ,1 6g/kg对S180 和HepA抑制率分别为47 3 %和 5 2 9%。结论

To study the antitumor effects of Polyg onum paleaceum alcohol extractive (PPE). Methods: Trypan blue dye exclusion and MTT metho ds were used in vitro, transplanted tumor of mice S180 and HepA were used in viv o. Results: IC 50 of PPE on K562 and HL60 at 24h were 26.2 and 36.7mg/L respectively in vitro, and in vivo the inhibition r ates of 1.6g/kg PPE on S180 and HepA were 47.3% and 52.9%, respectively. Conclusion: PPE exerts antitumor activity.