针刺对Ⅱ型糖尿病患者血清生长激素的影响

Influence of Acupuncture on Serum Growth Hormone Level in Patients with Type Ⅱ Diabetes

目的 :观察针刺对Ⅱ型糖尿病患者血清生长激素 ( growthhormone,GH)的影响 ,以探讨其作用机理。方法 :采用放射免疫法 (RIA)测定单纯针刺组 ( 1 8例 )、针药联合组 ( 52例 )及单纯药物组 ( 50例 )治疗前后的GH含量 ,并进行组间统计学处理。结果 :针药联合治疗与单纯针刺可明显降低患者的GH浓度 (P <0 .0 1 ) ,与单纯药物组比较 ,具有显著性差异 (P <0 .0 5,P <0 .0 1 )。结论 :针刺可通过调节Ⅱ型糖尿病患者生长激素水平 。

Objective: To observe the influence of acupuncture on plasma growth hormone (GH) level in patients with type Ⅱ diabetes for analyzing its action mechanisms. Methods:A total of 120 cases of diabetes patients were randomly divided into simple acupuncture group (n=18 cases), acupuncture+drug group (n=52) and simple drug group (n=50).Plasma GH content was detected with radioimmunoassay.Acupoints of Pishu (BI 20), Shenshu (BL 23),Qihai (CV 6),Quchi (LI 11),Neiguan (PC 6), Zusanli (ST 36), etc, stimulated with uniform reinforcing reducing method first for 15 min and then stimulated electrically with frequency of 80～100 Hz,a tolerable strength and duration of 15 min. The treatment was given once daily,with 10 sessions being a therapeutic course. In simple drug group and acupuncture +drug group,patients were ordered to take Glipizide (2.5～5 mg, 3 time/d), Metformin hydrochloride (0.25～0.5 g,3 times/d),etc.Results:After 2～3 courses of treatment,the levels of GH and fasting blood glucose were reduced obviously in the 3 groups particularly in acupuncture+drug group (P<0.05～ 0.001).Comparison of the difference values (post treatment minus pre treatment) of GH in 3 groups showed that the therapeutic effect of acupuncture +drug group was superior to that of the rest two groups (P<0.05～0.01),and that of simple acupuncture group superior to that of simple drug group (P<0.05). Conclusion: Acupuncture may regulate the level of plasma growth hormone in patients with type Ⅱ diabetes and improve hyperglycemic state.