乙肝Ⅱ号治疗慢性乙型病毒性肝炎时的抗氧自由基作用

Effects of Hepatitis B Mixture (HBM Ⅱ) on Antioxidation during the Treatment of Chronic Virus Hepatitis B

目的:研究乙肝Ⅱ号治疗慢性乙型肝炎时的抗氧自由基作用及其机制。方法:采用乙肝Ⅱ号治疗慢性乙型肝炎40例。现察患者血清过氧化脂质(LPO)含量、超氧化物岐化酶(SOD)及谷胱甘肽过氧化物酶(GSH-Px)活力以及丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)的变化。结果:乙肝Ⅱ号治疗组,治疗后LPO含量下降,SOD、GSH-Px活力上升,ALT、AST明显降低,数据显示:AlT、AST与SOD、GSH-Px呈负相关,与LPO呈正相关。结论:乙肝Ⅱ号对慢性乙型肝炎患者具有恢复肝功能、抗氧自由基的作用。

To study the relation among treatment of chronic virus hepatitis B with HBM Ⅱ and antioxi- dation and mechanism. Methods: 40 cases of chronic virus hepatitis B were treated with HBM Ⅱ . Then the oxidation indexes (from blood samples) and boichemical indexes such as ALT, AST were measured. Results: HBM Ⅱ showed some effect on changes of superoxide dismutase (SOD), Glutathtone peroxidase (GSH-Px), ALT and AST. These results suggested that there was a postive correlation between ALT, AST and LPO,there was a negative correlation between ALT, AST and SOD, GSH-Px. Conclusion: HBM Ⅱ showed some antioxidation and recovery effect of hepatic function on patients with chronic virus hepatitis B.