SSRIs类药物治疗儿童少年情绪障碍229例疗效观察

Efficacy of SSRIs in the treatment of 229 adolescent outptients with affective disorders

目的 了解SSRIs类药物在儿童少年情绪障碍治疗中的疗效与副反应。方法 自制调查表,回顾分析229例应用SSRIs类药物治疗儿童少年情绪障碍的各项资料。结果 药物平均起效时间16.6天。平均有效剂量:舍曲林30.8 mg,氟西汀与帕罗西汀均接近于20 mg。总有效率62.9％(脱落32.8％),副作用发生率11.8％(脱落18.5％)。结论 SSRIs类药物起效时间仍未短于2周,疗效与环类抗抑郁剂不相上下,而服用方便,副作用轻,在治疗儿童情绪障碍中前景广阔。

Objectives: To explore the efficacy and side effects of SSRIs in the treatment of adolescent affective disorders. Method: The data of 229 cases of adolescents with affective disorders receiving SSRIs were retrospectively collected and analysed. Results: The mean time of onset of effectiveness ws 16. 6days. The mean daily therapeutic doses of sertralin, paroxetine and fluoxetine were 30 mg, 20 mg and 20 mg, respectively. The overall response rate was 62. 9% (dropout rate for 32. 8%) and the occurrence of side effects was 11. 8% (dorpaut rate for 18. 5%). Conclusion: The effectiveness of SSRIs treatment occurred beyond two weeks, they were simply taken and had minimal side effects.