手性环丁内酯取代的氨基噻二唑的合成研究

SYNTHESIS OF NOVEL CHIRAL LACTONE SUBSTITUTED 2-AMINO-THIADIAZOLE

探讨了手性源 (R) (- ) 5 [(1R) 孟氧基 ] 2 (5H) 呋喃酮与氨基噻唑类化合物的不对称Michael加成反应 ,并利用该反应合成了 6个新型手性环丁内酯取代的氨基噻二唑类化合物 ,所有产物均经过1HNMR、IR、旋光度和元素分析等给予确证 .结果显示氨基噻唑中的氨基主要是从孟氧基所在位置的反面进攻 β 碳原子 .

Asymmetric Michael addition reaction of chiral ( R ) (-) 5 menthoxy] 2(5H) furanone with herterocycle amine with aromaticity is successfully investigated. And six novel chiral butyl lactone substituted amino thiadiazoles are prepared through the asymmetric Michael addition of 5 menthoxy 2(5H)furanone with amines thiadizoles. All the new compounds are identified on the bais of the spectroscopic data, such as IR, 1HNMR and specific rotation. Amino thiadiazoles react with chiral ( R ) (-) 5 2(5H) furanone with herterocycle amine with aromaticity is successfully investigated. And six novel chiral butyl lactone substituted amino thiadiazoles are prepared through the asymmetric Michael addition of 5 menthoxy 2(5H)furanone with amines thiadizoles. All the new compounds are identified on the bais of the spectroscopic data, such as IR, 1HNMR and specific rotation. Amino thiadiazoles react with chiral ( R ) (-) 5 menthoxy] 2(5H) furanone main from other side of menthoxy. 2(5H) furanone main from other side of menthoxy.