氟哌酸滴眼液对兔眼损伤型绿脓杆菌性角膜炎、角膜溃疡的预防和治疗

Prevention and Treatment of Pseudomonas Aeruginosa Keratitis and Corneal Ulcer in Rabbit with Norfloxacine Eyedrop

本文系用环钻损伤兔眼浅层角膜,感染绿脓杆菌,造成损伤型绿脓杆菌性角膜炎动物模型;采用氟哌酸滴眼液滴眼治疗。结果表明,氟哌酸滴眼液对绿脓杆菌性角膜炎具有明显的治疗作用,同时能有效地预防角膜溃疡的形成。

An animal model for Pseudomonas aeruginosa keratitis and corneal ulcer was establishedby injuring the superfical cornea of rabbit eyes with a trephine, and then infected with Pseudomonas aeruginosa. Treatment of this experimental keratitis with norfloxacine eyedrops showed an obvious therapeutic effect, which could also effectively prevent the formation of corneal ulcer.