2,5-二(对硝基苯基)-1,3,4-噻二唑的合成

Synthesis of 2,5-Di(p-nitrophenyl)-1,3,4-thiadiazole

通过对硝基苯甲酰氯与肼反应合成了对硝基苯甲二酰肼 ,后者与 P2 S5缩合反应合成了 2 ,5 -二对硝基苯基 -1 ,3,4 -噻二唑。研究了合成反应条件 ,使用吡啶作溶剂 ,收率 76 .2 %。经元素分析、IR,1 H NMR和 MS确证了产物的结构。生物活性初步研究表明 。

A new compound 2,5-di(p-nitrophyll)-1,3,4-thiadiazole was obtained via condensation of diarylhydrazide with P 2S 5. The yield is 76.2% when pyridine is used as a solvent. The structure of the compound was characterized by elementral analysis, IR and 1H NMR spectra. The results of preliminary bioassay showed that the new compound possessed fungicidal ativity.