一种新的β-环糊精衍生物手性固定相的制备及其气相色谱性能

A New Stationary Phase of β-Cyclodextrin Derivative and Its Chromatographic Performance

合成了一种新的手性固定相2,6_O_二丁基_3_O_三甲基硅烷基_β_环糊精 ,以甲基苯基硅油为稀释剂 ,采用快速超动态法 ,成功地将其涂渍到弹性石英毛细管柱上;柱性能稳定 ,柱寿命较长 ;用该柱分离了酯、酮。

A new alkylated and silylated β _ cyclodextrin derivative, 2,6 _ di _ O _ butyl _ 3 _ O _ trimethylsilyl _ β _ cyclodextrin, has been synthesized with trimethyl chlorosilane and bromobutane, and coated on a fused capillary column as a stationary phase with methyl _ phenylsilicone as a dilutent by rapidly superdynamical coating method. Chromatographic properties such as column efficiency, thermal stability and column life span, have been investigated. A series of enantiomers have been separated on the capillary column. Results show that the alkylated and silylated β _ cyclodextrin derivative is suitable for use as chiral stationary phase with good chromatographic properties in separating enantiomers.