米非司酮抑制卵泡发育的实验研究

EXPERIMENTAL STUDIES ABOUT MIFEPRISTONE IN RESTRAINING THE FOLLICLES FROM DEVELOPMENT

目的 :用组织学方法观察米非司酮抑制卵泡发育和排卵 ,探讨其避孕机制。方法 :取灌服米非司酮3天、7天大鼠的卵巢 ,光镜下观察卵泡的变化。结果 :生长卵泡、成熟卵泡及黄体随用药时间延长减少 ,闭锁卵泡和间质腺明显增多。结论 :米非司酮可抑制卵泡发育 。

Objective:To observe the effect of mifepristone(RU 486 )on restraining the follicle developing and ovulation with histology method and to explore the mechanism of contraception.Methods:After the RU 486 was a admistered for three days and seven days,the changes occurred in follicles was observed under the light microscope(LM).Results:With the admistering time prolonged the prowing follicles,mature follicles and corpus luteurn decreased,while the atresic follicles and interstitial glands increased.Conclusion:The RU 486 can exerted restraint effect on developing follicles,so RU 486 can be developed fully into peroral conception drug.