洛沙坦对高血压鼠肾小球硬化延缓作用的研究

The Inhibition of Losartan to Glomerulosclerosis in SHR

目的 探讨洛沙坦 (Losartan)对肾小球的保护作用。方法 由高血压组 (SHR)和正常对照血压组(WKY鼠 )组成 ,其中SHR组再分为治疗组和非治疗组 ,分别于 3月龄和 8月龄测量鼠尾动脉压及电子显微镜下有关超微结构计量指标。血管紧张素Ⅱ受体拮抗剂选用Losartan 2 0mg·Kg- 1·d- 1。结果 与正常血压对照组比较 ,高血压鼠血管内皮细胞、系膜细胞体密度明显增大 )P <0 0 1) ,显示增生较前者活跃 ,可见较多的电子致密物聚积并使整个系膜区体密度扩大 (P <0 0 1)。Losartan治疗后系膜区体密度及细胞外基质较非治疗组明显减小 (P <0 0 1)。结论 ATⅡ受体拮抗剂在降低动脉压同时 ,能有效地保护肾脏 。

Objective To investigate the mechanisms of angiotensinⅡ receptor blockade in protection against kidney lesion in hypertensive rats.Methods The investigation was comprised with normotensive control (WKY) and hypertensive group (SHR) which included treated and untreated group. Relevant index such as blood pressure and ultrastructural changes in glomerulus with transmission electronic microscope were acquired in three-month old and eight-month old. Losartan was administrated with 20mg·Kg -1 ·d -1 in treated group.Results The volume density of vessel endothelium, mesangial cells and mesangial area of SHR was significantly larger than that of WKY(P<0 01). With the treatment of losartan, SHR showed that certain decrease in volume density of vessel endothelium, mesangial cells and mesangial area(P<0 01). Conclusions Accompanied with the antihypertensive effect,angiotensinⅡ receptor antagonist could effectively inhibit the glomerulosclerosis development.