培哚普利对糖尿病大鼠肾脏的保护作用

Renal Protective Effect of Perindopril in Diabetic Rats

目的 观察培哚普利对糖尿病大鼠肾脏的保护作用。方法 雄性SD大鼠分为正常对照组 (NC)、糖尿病对照组 (DC)、糖尿病培哚普利治疗组 (DP) ,治疗 12周 ,比较各组大鼠尿白蛋白排泄 (UAE)的改变以及肾脏超微结构的改变。结果 DC组UAE显著高于NC组 ,DP组显著低于DC组 ;DC组肾脏超微结构表现为显著的基膜增厚、系膜增生 ,DP组上述改变明显减轻。

Objective To study the renal protective effect of perindopril in diabetic rats. Methods The following groups of rats were studied: normal control rats ,diabetic control rats and diabetic rats treated with perindopril (2mg·kg -1 ·d -1 ) . After 4 weeks or 12 weeks treatment , alterations of renal ultrastructure were observed in each group, Urinary albumin excretion was observed every 4 weeks.Results Urinary albumin excretion of diabetic rats treated with perindopril were significantly lower than that of diabetic untreated group(P<0 01).The ultrastructural alterations, including mesangial expansion and thickening of glomerular basement membrane(GBM) in diabetic rats treated with perindopril were lighter than those in diabetic control rats.Conclusion perindopril can reduce urinary albumin excretion and prevent renal pathological progress in diabetic rats. It suggested that peridopril may produce some renal protective effect in diabetic rats.