小剂量垂体后叶素加消心痛治疗肝硬化并发食管、胃底静脉曲张破裂出血疗效观察

The Observation on Treatment of Esophageal and Gastrical Bottom Varicosis Rupture Hemorrhage for Cirrhosis with Low Dose of Vasopressin and Isosorbide

87例肝硬化并发食道胃底静脉曲张破裂出血患者随机分成三组,34例给予小剂量垂体后叶素(0.1 U/min)和消心痛联合治疗,25例单用垂体后叶素(0.2U/min)治疗,28例用善得定治疗,其止血有效率分别为79.4％、56.0％、81.1％。经(?)检验治疗组较单用垂体后叶素组有显著性差异,而与善得定组无显著性差异。示垂体后叶素与消心痛联用止血疗效显著。

87 patients with esophageal and gastrical bottom varicosis rupture hemorrhage for cirrhosis were divided into three groups randomly. 34 cases were treated with low dose of vasopression (0. 1 μg/min), and isosorbide, 25 cases were treated with single vasopressin (0. 2 U/min) and 28 cases with sandostain. The control rates of bleeding were 79. 4%, 56. 0% and 81.1% respectively. By X' test, the combined therapy group (vasopressin and isosorbide) was significantly different from vasopressin group (P<0. 01), but not from sandostation group (P>0. 05). The results indicated that combination of vasopressin and isosorbide could significantly reduce portal hytertetion and obtained an eminent curative effection.