广西藤茶中杨梅树皮素的保肝作用研究

Experimental studies on protecting liver of myricetin

目的 :研究广西藤茶中杨梅树皮素的保肝作用。方法 :采用四氯化碳、D 半乳糖胺和异硫氰酸萘酯致小鼠急性肝损伤模型 ,观察杨梅树皮素对肝损伤的保护作用 ;采用小鼠单核巨噬细胞吞噬和免疫低下小鼠和溶血素试验 ,观察杨梅树皮素的免疫增强作用。结果 :杨梅树皮素能明显降低四氯化碳、D 半乳糖胺和异硫氰酸萘酯致小鼠急性肝损伤模型血清中ALT、AST活性和T BIL含量 ,减轻肝组织的变性和坏死 ;并提高单核巨噬细胞吞噬功能和溶血素含量。结论 :杨梅树皮素具有保肝降酶退黄 ,提高免疫功能作用。

To study the protecting liver of myricetin (MYR) in Ampelopsis grossedentata. Methods: The protecting liver, reducing enzyme activity and eliminating jaundice of MYR were observed using acute liver injury models induce by carbon tetrachloride (CCl 4), D galactosamine (D Gla) and naphthyl isothiocyanate (ANIT), and immunopotentiation action of MYR were studied by assay of mononuclear macrophage phagocytosis and hemolysin fromation in mice. Results: MYR could significantly lowered ALT?AST activities and T BIL contents in serum of acute liver injury models induced by CCl 4, D Gla and ANIT, lightening denaturation and necrosis of liver tissue, and increasing mononuclear macrophage phagocytosis and hemolysin content. Conclusion: MYR has the actions of protecting liver, reducing enzyme activity and eliminating jaundice.