甘草甜素和齐墩果酸对镉中毒肾损害的影响

Effects of Glycyrrhizin and Oleanolic Acid on Renal Histopathological Changes Induced by Subchronic Cadmium Exposure in Rats

目的 观察甘草甜素 (GL)和齐墩果酸 (OA)对大鼠亚慢性镉中毒性肾损害组织病理形态的影响。方法 光镜、电镜下观察CdCl2 组、CdCl2 +GL组、CdCl2 +OA组大鼠肾组织内肾小球、肾近曲小管的病理改变。结果 光镜下 ,CdCl2 +GL组、CdCl2 +OA组大鼠肾小球充血、肿胀、纤维化、肾近曲小管上皮细胞肿胀的程度较CdCl2 组明显减轻 ,范围有所缩小。超微结构观察示药物共处理组肾小球内组分、肾近曲小管细胞内线粒体等亚细胞组分的病变显著轻于CdCl2 组。结论 GL、OA对大鼠亚慢性CdCl2

Objective To observe effects of glycyrrhizin and oleanolic acid on renal histopathological changes induced by subchronic cadmium exposure in rats.Methods Renal glomemli,proximal tubular histopathological changes in CdCl\-2 -treated?CdCl\-2-GL,CdCl\-2-OA-cotreated rats were observed with light-microscopy and electro-microscopy.Results Renal glomeruli congestion,swelling and fibrosis, proximal tubular lining cells swelling in CdCl\-2-treated rats were significantly ameliorated by GL,OA cotreatments,which were revealed by light microscopy. Ultrastructure examination showed the pathologic changes in constituents of glomeruli and subcellular constituents like mitochondria in proximal tubular cells were less severe in GL,OA cotreated rats than those in CdCl\-2-treated rats.Conclusion GL and OA could improve the renal histophathological changes induced by cadmium in a subchronic model in rats.