人脑胶质瘤中Fas及FasL的表达

Fas and FasL expression in human gliona.

目的 探讨Fas及FasL基因在人脑胶质瘤中的表达 ,与肿瘤的病理类型及恶性程度的关系。方法 应用Fas及FasL多抗和Ki 6 7单抗免疫组化染色检测 6例正常脑组织及 6 4例人脑胶质瘤。结果 Fas和FasL在胶质瘤中的总表达率分别为 83%和 75 % ,并随WHO分级升高而升高 ,与Ki 6 7LI呈正相关。Fas、FasL共同阳性率 (共表达率 )为 71% ,与肿瘤级别呈正相关。

Objective To study the expression of Fas and FasL in human glionas and its relationship with histopathological type and degree of malignancy of glioma. Methods Fas/FasL expression, and Ki 67 labeling index (Ki 67LI) of 6 normal brain tissues, 64 glioma samples and 2 glioma cell lines were studied by immunohistochemical staining. Results Of the 64 gliomas, 53 (83%) expressed Fas, while 48 (75%) expressed FasL. The expression level increased with the increasing tumor grade, and positively correlated with Ki 67LI. The co expression rate was 71%, which was positively related with tumor grade. Conclusions Fas and FasL expression is related to histopathological type and degree of malignancy of gliomas.