5-取代芳氧基-3-戊炔-2-醇的合成研究

Studies on the synthesis of 5-aryloxy-3-pent-2-ol

研究了 3 芳基丙炔基醚 (硫醚 )的加成反应 ,区域选择性、高产率获得一系列的 5 芳氧基 3 戊炔 2 醇 。

The addition of 3-arylpropargyl ether with aldehyde has been described.A series of 5-aryloxy-3-pent-2-ol were obtained regioselectively in good yield.The key of reaction was using of the Grignard reagent of a terminal alkyne,prepared in situ by treatment of the alkyne with ethyl magnesium bromide in THF.