伊贝沙坦和西拉普利降压效果的比较

Efficacy of irbesartan and cilazapril on heart fuction in patients with mild to moderate essetial hypertension

目的 比较血管紧张素 受体拮抗剂伊贝沙坦和血管紧张素转化酶抑制剂西拉普利对轻、中度高血压患者降压效果及心功能的影响 .方法 6 0例轻、中度高血压患者 ,经 2wk洗脱期后 ,分为伊贝沙坦组和西拉普利组 ,每日分别服用伊贝沙坦 15 0～ 30 0 mg或西拉普利 2 .5～ 5 .0 mg,共 8wk.观察比较坐位血压、心率变化 ,对比服药前后超声心动图各指标 ,及实验室检查 .记录不良反应 .结果 治疗 8wk后 ,伊贝沙坦组总有效率为 80 .0 % ,西拉普利组总有效率为 73.3% ,两组比较无显著性差异 (P>0 .0 5 ) .与本组服药前比较 ,两组血压均有显著性下降 (P<0 .0 1) ,伊贝沙坦组较西拉普利组下降更为明显 (P<0 .0 5 ) .超声心动图二尖瓣舒张早期血流峰值 (E) ,二尖瓣舒张晚期血流峰值 (A) ,及 E/A比值 ,与本组服药前比较均有显著差异 (P<0 .0 1) ,两组间无显著性差异 (P>0 .0 5 ) .实验室检查及心电图无显著性改变 (P>0 .0 5 ) .结论 伊贝沙坦每日 15 0～ 30 0 mg治疗轻、中度原发性高血压 ,具有良好的降压作用 ,并且对高血压靶器官具有良好的保护作用 .

AIM To observe and compare efficacy and the effect of irbesartan and cilazapril on heart functions in patients with mild or moderate essential hypertension. METHODS Sixty patients with mild to moderate hypertension were treated with irbesartan 150～300 mg or cilazapril 2.5～5.0 mgdaily. For 8 weeks, sitting blood pressure, heart rate, echocardiography and laboratory examination of the patients were observed at baseline and post treatment. Adverse reactions were recorded. RESULTS After 8 weeks of treatment, efficacy was achieved in 80.0% of patients in irbesartan group and 73.3% in cilazapril group ( P >0.05). The decrease of sitting blood pressure was significant in both of the two groups ( P <0.01), irbesartan group was more significant ( P <0.05). In two groups, atiral peak filling velocity ( A ) was all decreased ( P <0.01), early peak filling velocity (E) and E/A radio were increased ( P <0.01); there were no statistical differences between irbesartan and cilazapril. Cilazapril administration induced dry coughing (10%) whereas irbesartan did not. CONCLUSION Irbesartan 150～300 mg dialy was effective in the treatment of mild to moderate essential hypertension, and can improve heart function.