反应停对增生性瘢痕细胞超微结构的影响

Thalidomide inhibits formation of hypertrophic scar

目的 为探讨血管形成抑制剂反应停对增生性瘢痕的治疗机制提供形态学依据 .方法 通过建立兔耳增生性瘢痕模型 ,观察血管形成抑制剂反应停对增生性瘢痕超微结构的影响 .结果 血管形成抑制剂反应停作用后增生性瘢痕组织中的毛细血管基膜不完整 ,内皮细胞变性 ,血管形成过程受损 ,成纤维细胞发生变性 ,内质网等细胞器减少 ,细胞外基质也相应减少 .结论 反应停可能是通过影响血管形成而致增生性瘢痕组织中的成纤维细胞变性 .因而血管抑制剂可抑制瘢痕增生 .

AIM To investigate the mechanism of the effect of thalidomide on hypertrophic scar. METHODS By establishing rabbit hypertrophic scar model, we observed the effect of thalidomide on the ultrastructure of hypertrophic scar. RESULTS Treated with angiogenesis inhibitor thalidomide, the basement membrane of capillary became unintegrated, the endothelial cells degenerated, and the procedure of angio genesis was damaged. The fibroblasts of hypertrophic sar became degenerated, the endoplasmic reticulum small and reduced, and the extra cellular matrix also reduced. CONCLUSION The degeneration of hypertrophic scar fibroblasts and endothelial cells may be caused by the inhibitory effect of thalidomide on angiogenesis. So the angiogenesis inhibitor can inhibit the formation of hypertrophic scar.