胃癌患者血浆可溶性P-选择素及血清唾液酸的变化

Variation of plasma soluble P-selectin and serum sialic acid in patients with gasric cancer

目的 观察胃癌患者血浆可溶性 P-选择素 (s P- se-lectin)和血清唾液酸 (SA)水平 ,探讨其临床意义 .方法 用EL ISA法和快速比色法分别测定 4 5例胃癌患者 ,4 0例胃溃疡患者及 30例正常人血浆 s P- selectin和血清 SA水平 .结果 胃癌患者血浆 s P- selectin水平 (110± 6 ) mg· L- 1 及血清SA水平 (94 0± 5 2 ) mg· L- 1 显著高于胃溃疡患者 (2 3± 3) mg· L- 1 ,(5 80± 4 7) mg·L- 1及正常人群 (2 1± 5 ) mg·L- 1 ,(5 5 0± 38) mg· L- 1 (P<0 .0 1,P<0 .0 1) ;胃癌患者 s P- selectin水平有脏器转移者 (12 1± 4 ) mg· L- 1 与无脏器转移者 (10 4± 3)mg·L- 1比较差异有显著性 (P<0 .0 5 ) ,而胃溃疡患者与正常人群之间比较无统计学意义 (P>0 .0 5 ) .结论 s P- selectin和 SA均参与了胃癌的发生发展 ,两指标对于良、恶性溃疡的鉴别有一定价值 .另外 ,s P- selectin还可作为有无转移的一项辅助指标 .

AIM To observe the plasma levels of soluble P selectin (sP selectin) and the serum levels of sialic acid (SA) in patients with gastric cancer and to assess their clinical significance. METHODS The plasma levels of sP selectin and the serum levels of SA were measured by ELISA method and rapid colorimetric determination method respectively. Forty five gastric cancer patients, 40 gastric ulcer patients and 30 healthy persons were determined. RESULTS The plasma levels of sP selectin and the serum levels of SA in patients with gastric cancer (110±6) mg·L -1 , (940±52) mg·L -1 were distinctly higher than those in patients with gastric ulcer (23±3) mg·L -1 , (580±47) mg·L -1 and those in the normal control group (21±5) mg·L -1 , (550±38) mg·L -1 respectively ( P <0.01, P <0.01). The plasma levels of sP selectin in patients with metastasis (121±4) mg·L -1 were higher than those in patients without metastasis (104±3) mg·L -1 ( P <0.05). CONCLUSION sP selectin and SA are both involved in the mechanism of genesis and development of gastric cancer. They are valuable for distinguishing benign from malignacy gastric ulcer. sP selectin can also be used as an assisting index to analyse gastric cancer with or without metastasis.