老年肺结核支气管肺泡灌洗液中肿瘤坏死因子(TNF-α)及白介素-1β的检测及临床意义

Clinical significance of TNF-α and IL-1βin bronchial aveloe lavage fluid of old patients with tuberculosis cavity

目的 探讨老年肺结核肺内炎症免疫效应细胞释放的细胞因子对老年空洞肺结核发病机制的影响。方法 采用双抗体夹心酶联法 (ELISA)检测 16例空洞肺结核患者血清及支气管肺泡灌洗液 (BALF)中 ,肿瘤坏死因子 α和白介素 1β的水平 ,并与 14例非空洞型肺结核相对照。结果 空洞型肺结核患者BALF中TNF α为 4 30 8± 10 3 8ng L ,IL 1β为 2 4 8 6± 88 2ng L ,明显高于对照组TNF α 6 9 2± 6 3ng L ,IL 1β 19 3± 4 6ng L的水平。结论 推测TNF α和IL

Objective: To evaluate the clinical significance of TNF α and IL 1β in the formation of tuberculosis cavity Methods: Contents of TNF αand IL 1βin BALF of 16 patients with tuberculosis cavity and 14 with non tuberculosis cavity were determined with ELISA method Results: It was found that the concentation of TNF α and IL 1β of BALF in patients with tuberculosis cavity were obviously higher than that of BALF in patients with non cavial tuberculosis (430 8±103 8 ng/L VS 69 2±6 3 ng/L, 248 6±88 2 ng/L VS 19 3±4 6 ng/L respectively P<0 001) Conclusion: The results indicate that TNF α and IL 1β might play an important role in reducing the formation of tuberculosis cavity