80例急性血吸虫病人吡喹酮疗效的追踪观察

Evaluation of cure with priziquantel for 80 cases of acute schisitosomiasis in the field

目的 现场评价吡喹酮治疗急性血吸虫病的效果。方法 80例急性血吸虫病人经吡喹酮治疗后的次年开始 ,采用询检、体检、肝功能检查和B超以及粪检、IHA、ELISA等诊断方法进行 6年随访追踪观察。结果 以粪检阳性是否转阴作为治愈与否的标准 ,治后 4年治愈率为 10 0 % ;血清免疫学实验 2年内无明显转阴 ,自第 3年起部分转阴 ,治后 5年IHA和ELISA的阴转率分别达到 93 4%和 90 0 %。观察期间 ,粪检完全转阴后 ,仍然有2例急血病人转化为晚期血吸虫病患者。结论 吡喹酮有效治疗急性血吸虫病人后 。

Objectives To value the efficacy of priziquantel used to treat patients with the acute schistosomiasis in endemic areas in Huarong county, Hunan province. Methods 80 persons with the acute schistosomiasis were surveyed longitudinally from the second year to the sixth years after treated with priziquantel. The observed objects were examined by methods of inquring, pysical examination,liver function test and ultrosound, fecal examination and IHA,ELISA etc. Results The negative conversion rate of stool examination was 100% at 4 years after chemotherapy by priziquantel. For immunological diagnostic methods,it had no changed at the first two years but it has an exception at 3 years after treatment. The negative conversion of IHA and ELISA methods were 93.4% and 90.0% at 5 years after chemotherapy, respectively. Although some patients with schisitosomiasis has few eggs excretion in feces at 4 years after chemotherapy, the patients were still developing to the late stage during the observed time. Conclusion The data suggested that some cases of the acute schisitosomiasis were cured with priziquantel and supplementary treatment to their liver, but the measure could not keep the patients from the advanced schistosomiasis.