乳腺癌中雌激素受体、孕酮受体、p53、c-erbB-2基因的表达及其意义

Expressions of estrogen receptor(ER),progestrone receptor(PR),p53 and c-erbB-2 genes in human breast cancer

目的 探讨雌激素受体 (ER)、孕酮受体 (PR)、p5 3、c erbB 2基因表达与乳腺癌预后的关系。 方法 用免疫组织化学S P法检测 4 5例浸润性乳腺癌、2 4例癌旁组织、2 0例乳腺增生症ER、PR、p5 3、c erbB 2基因的表达水平。 结果 4 5例乳腺浸润性癌中ER、PR、p5 3、c erbB 2基因的阳性率分别为6 0 .0 %、4 4 .4 %、5 1.2 %、5 5 .3% ;在 2 4例癌旁组织中的阳性率分别为 10 0 %、10 0 %、2 5 .0 %、4 .17% ;在2 0例乳腺增生症中阳性率分别为 10 0 %、10 0 %、10 .0 %、15 .0 %。乳腺癌淋巴结转移者与无淋巴结转移者 p5 3、c erbB 2基因表达的阳性率差异有统计学意义 (P <0 .0 5、P <0 .0 1)。 结论 同时检测ER、PR、p5 3、c erbB 2基因产物对乳腺癌的病理诊断、预后判断及指导治疗均有重要的临床意义及实用价值。

Objective To explore the relationship among expressions of ER,PR,p53,c erbB 2 genes and prognosis of breast cancer. Methods The expressions of ER,PR,p53 and c erbB 2 genes in 45 cases with invasive breast cancer and 20 cases with breast adenosis were tested by Immunohistochemical assay(S P). Results The positive rate of ER,PR,p53,c erbB 2 genes expression in 45 cases with breast cancer was 60.0 %,44.4%,51.2% and 55.3%, respectively. The positive rate of p53,c erbB 2 genes expression in 20 cases with breast adenosis was 10.0%and 15.0%,respectively. The over expressions of p53,c erbB 2 genes were correlated only with the lymph node metastasis. Conclusion To test ER,PR,p53,c erbB 2 at the same time is very important for the pathological diagnosis, estimation of prognosis and treatment of breast cancer.