颈动脉粥样硬化与冠状动脉粥样硬化的关系

Relationship between carotid atherosclerosis and coronary atherosclerosis in elderly patients with coronary artery disease

目的 探讨颈动脉粥样硬化与冠状动脉粥样硬化的关系。方法 对 94例老年患者进行了冠状动脉造影和颈动脉超声检查。颈动脉粥样硬化斑块积分采用Sutton法。结果 单支组及多支组内膜中膜厚度、斑块积分显著高于正常组 ,多支组显著高于单支组 (P<0 .0 5 )。斑块指数与年龄、吸烟、低密度脂蛋白胆固醇与高密度脂蛋白胆固醇的比值、收缩压以及高血压病程的程度呈正相关。

Objective To evaluate the relationship between carotid atherosclerosis (CAS) and coronary atherosclerosis in elderly patients with coronary artery disease.Methods Carotid ultrasonography was performed in 94 patients who had been examined by coronary angiography. Carotid plaque score was calculated using Sutton's method to quantify the extent of carotid atherosclerosis.Results The carotid intima media thickness and plaque index were significantly increased in all diseased groups versus controls(P<0.05). Multiple regression stepwise analysis of all the subjects revealed that the age, cigarette smoking, systolic blood pressure,course and severity of hypertension, high density lipoprotein cholesterol (HDL C), ratio of low density lipoprotein cholesterol (LDL C) and HDL C were independently positively correlated with CAS.As coronary atherosclerosis progressed, the extent of CAS increased. Significant differences of carotid plaque scores were found between different coronary artery disease groups (P<0.01).Conclusion The results suggest that the coronary artery disease and cerebral artery disease are parellel.