博来霉素化疗的同期联合放疗治疗头颈部中晚期鳞癌

Observation of Bleomycin Chemotherapy Plus Radiotherapy for Cephalocervical Part Middle-advanced Stage Squamous Epithelial Carcinoma

目的 观察使用博来霉素化疗的同期给予放疗治疗头颈部中晚期鳞癌的疗效。方法 62例头颈部中晚期鳞癌患者随机分为观察组和对照组。观察组 3 2例 ,每天用博来霉素 8mg加地塞米松 5 mg,静滴 ,1次 / d,化疗后采用直线加速器放疗。5次 /周 ,2 Gy/次 ,照射总量 60～ 70 Gy,博来霉素总量 1 60～ 2 0 0 mg。对照组 3 0例 ,给予单纯放疗治疗 ,剂量同观察组。结果 观察组和对照组在放疗 40 Gy及放疗结束后 3个月 ,颈淋巴结消退率分别为 :44% ,3 0 %和 88% ,73 % (P<0 .0 5 ) ,毒副反应均较轻。结论 博来霉素化疗同期进行放疗 ,有利于提高头颈部中晚期鳞癌患者淋巴结转移灶全消率 ,减少残存 。

Objective To evaluate the therapy effect of bleomycin chemotherapy plus radiotherapy for cephalocervical part middle advanced stage squamous epithelial carcinoma Methods 62 middle advanced stage squamous epithelial carcinoma cases were random devided into observation group (32 cases) and control group (30 cases) For observation group: bleomycin 8 mg plus dexamethasone 5 mg, ID, 1/d Radiotherapy with linear accelerator was used after chemotherapy, 5/week, 2 Gy/time, the total irradiation dosage was 60-70 Gy The total bleomycin dosage was 160-220 mg For control group, the patients received simple radiotherapy Results When the patients of the observation group and control group received 40 Gy irradiation dosage, the lymphomodi cervicales extinction rates respectively were 44% and 30% 3 months after radiotherapy ended, the lymphomodi cervicales extinction rates respectively were 88% and 73% ( P <0.05) The toxic reaction was all slight Conclusion The therapy effect of bleomycin chemotherapy plus radiotherapy for cephalocervical part middle advanced stage squamous epithelial carcinoma is definite