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胶原代谢与糖尿病肾病 被引量:6

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摘要 糖尿病肾病 (DN)的发生发展涉及多个环节。胶原蛋白是细胞外基质中最丰富的结构成分 ,在组织修复、纤维化等病理生理过程中起重要作用。在DN ,胶原代谢出现异常 ,血清、尿中胶原蛋白含量增加 ,肾组织内编码胶原蛋白的mRNA水平及其表达水平均增高 ,提示胶原蛋白在DN的发生、发展中起重要作用。胶原代谢的异常与高血糖、蛋白质非酶糖化、细胞因子等有关。应用干预措施降低胶原蛋白表达有助于阻抑DN的发生。
作者 李丹清
出处 《国外医学(内分泌学分册)》 2002年第3期188-191,共4页 Foreign Medical Sciences(Section of Endocrinology)
基金 辽宁省教委科研课题 (编号 :990 2 2 14 36 )
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