肌瓣转移修复口腔粘膜缺损后肌组织的形态学变化

Morphologic changes of the muscle flap for reconstruction of oral defect

目的 观察肌瓣转移修复口腔粘膜缺损后深层肌组织的形态学变化。方法 14只新西兰白兔人为造成口腔粘膜缺损 ,将兔胸骨乳突肌转移到缺损区 ,保留副神经支配 7只 ,切断神经 7只 ,术后 1、2、3、4、8、12、2 0周对肌组织进行光镜和透射电镜观察。结果 保留运动神经支配的肌组织显微和超微结构变化不明显 ,萎缩程度轻 ;而切断运动神经支配的肌组织形态变化严重 ,失去正常结构 ,萎缩明显 ,形成瘢痕样组织。结论 肌瓣转移修复口腔缺损 ,保留运动神经支配可基本保持肌组织的正常形态 。

Objective To observe the morphologic changes of the muscle flap used for intraoral reconstruction.?Methods Intraoral defects were made in 14 New Zealand white rabbits, and the sternomastoid muscle flaps were transferred to repair the oral defects.The transferred flaps,7 of which were innervated and 7 were denervated, were studied by light microscopy and transmission electron microscopy after 1,2,3,4,8,12 and 20 weeks.?Results The innervated muscle showed better integrity compared with the denervated muscle, and the latter developed more atrophy and scarring.?Conclusion These findings suggest that innervated muscle flaps are the choice for functional reconstruction.