SLE患者尿视黄醇结合蛋白和微量白蛋白联合检测的临床价值

The clinical significance of urinary excretion of retinol binding protein and albumin in SLE

目的 探讨系统性红斑狼疮 (SLE)患者尿液中视黄醇结合蛋白 (RBP)和微量白蛋白 (ALb)联合检测的临床意义。方法 对 37例SLE患者尿液样本进行RBP和ALb的联合测定。结果 37例SLE患者RBP和ALb明显高于正常对照 (P <0 .0 1)。 2 5例无明显肾损害的临床表现 ,尿总蛋白浓度低于 0 .3g/L ,尿蛋白定性为阴性的患者中有 2 0例尿RBP或ALb单一指标升高 ,5例两项均升高。结论 在无明显肾脏疾病情况下 ,尿RBP或ALb增高 ,能够提示亚临床型肾脏损伤 。

Objective To discuss the clinical significance of urinary excretion of retinol-binding protein (RBP) and albumin (Alb) in SLE. Methods The urinary BP and Alb were examined from 37 patients with SLE and 50 normal subjects. Results The average values of urinary RBP and Alb were significantly higher in SLE patients than in normal control (P< 0.01). Among the 25′ urine protein test negative′ SLE, who had no apparent clinical evidence of renal impairment and a total urinary Alb less than 0.3 g/L, 20 had elevated contents of either RBP or Alb in urine, while the other 5 had elevated contents of the both, compared with that of the control. Conclusion In the absence of clinical evidence of renal involvements, increases in urinary RBP or Alb can indicate subclinical nephropathy in SLE and their measurement may help its early diagnosis and adequate monitoring.