皮下埋植式药泵动脉灌注化疗治疗大肠癌肝转移

Hepatic Artery Infusion Chemotherapy with Implanted Pump for Liver Metastases of Colorectal Carcinoma

[目的]探讨采用经皮下埋植式药泵肝动脉栓塞化疗治疗大肠癌肝转移的近期疗效、生存期及并发症。[方法]泵内化疗组24例采用经皮下埋植式药泵肝动脉栓塞化疗 ,对照组20例采用静脉化疗。[结果]泵内化疗组近期疗效 (CR +PR)为79.1% ,静脉化疗组为15% ,经检验两组差异有显著性 (P<0.05) ;泵内化疗组6个月、12个月、24个月的生存率分别为83.7%、63.5%、41.9% ,而静脉化疗组6个月、12个月、24个月的生存率分别为54.5%、29.7 %、14.6% ,经检验两组差异有显著性 (P<0.05)。[结论]采用经皮下埋植式药泵肝动脉栓塞化疗是治疗大肠癌肝转移安全、有效的方法之一 。

To evaluate the efficacy and side_effect of hepatic artery infusion chemotherapy with implanted pump in the treatment of liver metastases for colorectal carcinoma.Hepatic artery infusion chemotherapy was performed in 24 cases (study group),and systemic chemotherapy was given to 20 cases (control group).The short term response rate was 79.1% in study group, and 15% in control group. There was significant difference between two groups(P<0.05). For study group, the survival rate of 6,12 and 24 months was 83.7%, 63.5% and 41.9%, respectively, while for control group was 54.5%,29.7% and 14.6% ,respectively. There was a significant difference in survival between the two groups (P<0.05).[Conclusion]Hepatic artery infusion chemotherapy with implanted pump is a safe and effective therapy for the treatment of liver metastases for colorectal carcinoma. Compared with conventional systemic chemotherapy, it can improve the efficacy and survival.