纳米碳改性聚氨酯复合材料的表面抗凝血性能

Resistance to surface blood coagulation by the nano-Carbon modified polyurethane composite

研究纳米碳改性聚氨酯复合材料表面的血液相容性。将经过表面处理的纳米碳分散到聚氨酯体系中 ,制成聚氨酯 纳米碳复合薄膜。通过血小板荧光标记人全血灌注实验和羊全血体外循环等实验 ,观察和测定血小板在材料表面的粘附作用以及血液中血红蛋白浓度、纤维蛋白原浓度的变化 ,探讨纳米碳对聚氨酯抗凝血性能的影响。实验结果显示聚氨酯 纳米碳表面血小板的粘附明显低于单纯聚氨酯对照组 ;体外循环 4h后 ,血液中血红蛋白浓度、纤维蛋白原浓度的变化程度减小。表明纳米碳与聚氨酯的复合可以提高材料的血液相容性。

To investigate the effects of blood compatibility on composite surface for nano-sized carbon as a dispersed phase of polyurethanes. A novel nano-scale polymeric composite film was prepared by dispersing nano-sized carbon into the polyurethane solutions. The surface blood compatibilities of the composites were analyzed and evaluated through platelet adhesion measurement using epifluorescent video microscopy and the variation of fibrinogen and free haemoglobin concentration in the blood contacting the composite respectively. The changes of the concentration of both free haemoglobin and fibrinogen in the blood contacting the composite surface are less than the ones contacting the reference surface. Introducing nano-sized carbon into the polyurethane matrix showed an improvemed antithrombogenicity by polyurethane materials.